Poly(ADP-ribose) Glycohydrolase (PARG)
Poly (ADP-ribose) glycohydrolase (PARG) is the primary hydrolase involved in the degradation of poly(ADP-ribose) (PAR). PARG possesses both endo-glycohydrolase and exo-glycohydrolase activity, preferentially performing the latter by binding to the two most distal ADP-ribose residues within the PAR chain. These different modes of catalysis produce free PAR and mono ADP-ribose moieties, respectively. The free mono ADP-ribose is then metabolized into AMP and ribose 5′ phosphate by ADP-ribose pyrophosphohydrolases such as the NUDIX family. AMP is utilized in ATP reformation and different metabolic and cell signaling pathways while ribose 5′ phosphate is a precursor to many biomolecules including DNA, RNA and ATP. Endo-glycohydrolase activity is considered to occur primarily during hyper-PARP activation, the resulting free PAR chains produced are then implicated in apoptosis acting as a death signal.
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Poly(ADP-ribose) Glycohydrolase (PARG) Related Products (27)
Related Products (27)
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Antibodies (6)
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TFMU-ADPr
0 ImagesCat. No.: HY-146248CAS No.: 2412923-11-4TFMU-ADPr is a selective reporter substrate of SARS-CoV-2 Macro1 (IC50=0.59 μM), with an excitation wavelength (λEx) of 385 nm, and an emission wavelength (λEm) of 502 nm (or 495 nm). TFMU-ADPr can also undergo enzymatic hydrolysis with Poly(ADP-ribose) Glycohydrolase (PARG) sourced from human, Tetrahymena thermophila and ADP-ribosylhydrolase 3 from human to release fluorophores, thereby directly reporting total poly (ADP-ribose) hydrolase activity. TFMU-ADPr binds to the ADPr-binding site of SARS-CoV-2 Macro1, and its TFMU moiety inserts into the narrow hydrophobic groove of this protein. TFMU-ADPr can thus be used to evaluate small-molecule inhibitors targeting PAR hydrolases under in vitro conditions, to investigate the regulatory mechanisms of ADP-ribosyl catabolic enzymes, or to detect PAR hydrolase activity in whole-cell lysate assays. TFMU-ADPr is also applicable to COVID-19-related research.
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Etidaligide sodium
0 ImagesCat. No.: HY-177631ASynonyms: DT01 sodium; coDbait sodium
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pNP-ADPr
0 ImagesCat. No.: HY-134354CAS No.: 939028-75-8Synonyms: ADP-ribose-pNP
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PDD00031704
0 ImagesCat. No.: HY-177420CAS No.: 2032096-42-5PDD00031704 is a poly (ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of > 60 µM.
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PARP-1-IN-32
0 ImagesCat. No.: HY-164757CAS No.: 374069-33-7PARP-1-IN-32 (compound 15) is a poly (ADPribose) polymerase-1 (PARP-1) inhibitor. PARP-1-IN-32 can be used in cancer research.
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Gatuzosiran sodium scrambled negative control
0 ImagesCat. No.: HY-177634BGatuzosiran sodium scrambled negative control is the sequence scrambled negative control of Gatuzosiran sodium.
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PDD 00017273 (Standard)
0 ImagesCat. No.: HY-108360RCAS No.: 1945950-21-9PDD 00017273 (Standard) is the analytical standard of PDD 00017273 (HY-108360). This product is intended for research and analytical applications. PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a Kd of 1.45 nM.
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